February, 2018 update

    • LIPID MAPS® Highlights

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    • Lipid of the month


      ELV-N34, (Systematic Name:(16Z,19Z,22R,23E,25E,27Z,29S,31Z)-22,29-dihydroxydotetratriaconta-16,19,23,25, 27,31-hexaenoic acid) represents a novel class of lipid mediators biosynthesized in human retinal pigment epithelial (RPE) cells that are oxygenated derivatives of very long-chain polyunsaturated fatty acids (VLC-PUFAs,n-3). These mediators have been named elovanoids (ELV) and are necessary for neuroprotective signaling for photoreceptor cell integrity. Photoreceptor cells express the elongase enzyme ELOVL4 which catalyzes the biosynthesis of elovanoids from 22:6 fatty acids derived from DHA or EPA.

      Lipid of the month archive

"Lipid Matters - A Personal Blog" — by William (Bill) W. Christie

Feb 14th, 2018

In plants, glycerolipid biosynthesis in chloroplasts has long been termed the "prokaryotic pathway", and it produces galactosyldiacylglycerols and phosphatidylglycerol with C18 acids in position sn-1 and C16 acids in position sn-2. This pattern is seen in cyanobacteria and it has been assumed that the similarity was a consequence of endosymbiosis during evolution. A new study demonstrates that this is not true …

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Key LIPID MAPS® Resources
- publications related to projects funded through the LIPID MAPS® consortium
Lipid Classification System
- the first internationally accepted lipid classification system
Lipid Standards
- MS/MS spectra, annotations for principal product ions, and acquisition parameters
Experimental Data
- centralized studies on macrophages, lipidomics data on human plasma, and more
Structure Database (LMSD)
- over 40,000 unique structures of biologically relevant lipids
Proteome Database (LMPD)
- over 12,500 lipid-associated proteins from major research species
- manually curated lipid metabolism and signaling pathways
- web-based/programmatic access to lipid structure and lipid-related gene/protein data
MS analysis tools
- tools for searching various lipid classes by precursor or product ion
Structure Drawing Tools
- draw and save lipid structures using online menus
- LIPID MAPS® techniques for lipidomics and macrophage cell culture

LIPID MAPS® is funded by a grant from the Wellcome Trust.

logo LIPID MAPS® is funded by a grant from the Wellcome Trust.