November, 2017 update

    • LIPID MAPS® Highlights

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    • Lipid of the month


      2OG2-oleoyl-glycerol

      2-oleoyl-glycerol (Systematic Name:2-(9Z-octadecenoyl)-sn-glycerol) is a monoacylglycerol that is found in biological tissues. Monoacylglycerols or monoglycerides are a class of glycerolipids which are composed of a molecule of glycerol linked to a fatty acid via an ester bond. They are typically present at low levels in cell extracts but are intermediates in the degradation of triacylglycerols and diacylglycerols (lipolysis). 2-oleoyl-glycerol was found to be an endogenous ligand to the G protein-coupled receptor GPR119 and has been shown to increase glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) levels following administration to the small intestine.

      Lipid of the month archive

"Lipid Matters - A Personal Blog" — by William (Bill) W. Christie

Nov 15th, 2017

The hedgehog proteins are among my favourite molecules as they stick up two metaphorical fingers to nutritionists. The first such finger is cholesterol, which is covalently bound to the C-terminus, while the second is palmitic acid covalently bound to the N-terminus. Although they are anethema in some quarters, the vital importance of the two much maligned lipid components is clearly demonstrated …

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Key LIPID MAPS® Resources
Publications
- publications related to projects funded through the LIPID MAPS® consortium
Lipid Classification System
- the first internationally accepted lipid classification system
Lipid Standards
- MS/MS spectra, annotations for principal product ions, and acquisition parameters
Experimental Data
- centralized studies on macrophages, lipidomics data on human plasma, and more
Structure Database (LMSD)
- over 40,000 unique structures of biologically relevant lipids
Proteome Database (LMPD)
- over 12,500 lipid-associated proteins from major research species
Pathways
- manually curated lipid metabolism and signaling pathways
LIPID MAPS® REST Service
- web-based/programmatic access to lipid structure and lipid-related gene/protein data
MS analysis tools
- tools for searching various lipid classes by precursor or product ion
Structure Drawing Tools
- draw and save lipid structures using online menus
Protocols
- LIPID MAPS® techniques for lipidomics and macrophage cell culture

LIPID MAPS® is funded by a grant from the Wellcome Trust.

logo LIPID MAPS® is funded by a grant from the Wellcome Trust.