LMPD Database

LMP000026

UniProt Annotations

Entry Information
Gene Namesolute carrier family 27 (fatty acid transporter), member 2
Protein EntryS27A2_MOUSE
UniProt IDO35488
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Catalytic ActivityATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.
FunctionAcyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism (By similarity). May be involved in translocation of long-chain fatty acids (LFCA) across membranes. {ECO:0000250, ECO:0000269|PubMed:15699031}.
Sequence CautionSequence=AAC40186.1; Type=Frameshift; Positions=253, 263, 267, 281, 289, 293, 299, 301, 307; Evidence={ECO:0000305};
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Peripheral membrane associated with the lumenal side of peroxisomes. {ECO:0000250}.
Tissue SpecificityStrong expression in liver and kidney, low expression in brain and testis, no expression in skeletal muscle and spleen. Shows uniform distribution in liver acinus. {ECO:0000269|PubMed:11980911}.