LMPD Database

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LMP000074

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 4
Protein EntryDHB4_MOUSE
UniProt IDP51660
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity(24R,25R)-3-alpha,7-alpha,12-alpha,24- tetrahydroxy-5-beta-cholestanoyl-CoA = (24E)-3-alpha,7-alpha,12- alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O.
Catalytic Activity(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O.
Catalytic Activity(R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
FunctionBifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids (By similarity). {ECO:0000250}.
MiscellaneousThe protein is found both as a full length peptide and in a cleaved version. {ECO:0000250}.
PathwayLipid metabolism; fatty acid beta-oxidation.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
SimilarityContains 1 MaoC-like domain. {ECO:0000305}.
SimilarityContains 1 SCP2 domain. {ECO:0000305}.
Subcellular LocationPeroxisome {ECO:0000250}.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityPresent in many tissues with highest concentrations in liver and kidney.