LMPD Database

LMP000139

UniProt Annotations

Entry Information
Gene Nameapolipoprotein A-II
Protein EntryAPOA2_MOUSE
UniProt IDP09813
SpeciesMouse
Comments
Comment typeDescription
DiseaseNote=Defects in Apoa2 are the cause of senescence accelerated mouse (SAM), the senile amyloid is a mutated apolipoprotein A-II.
FunctionMay stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Mass SpectrometryMass=8709.2; Mass_error=0.071; Method=Electrospray; Range=24-102; Note=Strain C57BL/6. Without methionine sulfoxide.; Evidence={ECO:0000269|PubMed:16876491};
Mass SpectrometryMass=8719.5; Method=Electrospray; Range=24-102; Note=Strain BALB/c. Without methionine sulfoxide.; Evidence={ECO:0000269|PubMed:16876491};
Mass SpectrometryMass=8725.3; Mass_error=0.283; Method=Electrospray; Range=24-102; Note=Strain C57BL/6. With 1 methionine sulfoxide.; Evidence={ECO:0000269|PubMed:16876491};
Mass SpectrometryMass=8735.2; Method=Electrospray; Range=24-102; Note=Strain BALB/c. With 1 methionine sulfoxide.; Evidence={ECO:0000269|PubMed:16876491};
Mass SpectrometryMass=8742; Method=Electrospray; Range=24-102; Note=Strain C57BL/6. With 2 methionine sulfoxides.; Evidence={ECO:0000269|PubMed:16876491};
Mass SpectrometryMass=9294; Mass_error=0.707; Method=Electrospray; Range=19-102; Note=Strain C57BL/6. Without methionine sulfoxide.; Evidence={ECO:0000269|PubMed:16876491};
Mass SpectrometryMass=9304; Method=Electrospray; Range=19-102; Note=Strain BALB/c. Without methionine sulfoxide.; Evidence={ECO:0000269|PubMed:16876491};
MiscellaneousThe apo A-II stoichiometry in HDL molecules varies among inbred mice strains, because of structural polymorphisms affecting the apo A-II gene, which influence its translational efficiency.
MiscellaneousThe sequence presented here is that of strain BALB/c and C3H/HeJ.
PtmPhosphorylation sites are present in the extracellular medium. {ECO:0000250}.
SimilarityBelongs to the apolipoprotein A2 family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitMonomer. Interacts with APOA1BP and NDRG1 (By similarity). {ECO:0000250}.
Tissue SpecificityPlasma.