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LMP000368

Record overview

LMPD IDLMP000368
Gene ID80765
SpeciesHomo sapiens (Human)
Gene NameStAR-related lipid transfer (START) domain containing 5
Gene SymbolSTARD5
Synonyms-
Alternate namesstAR-related lipid transfer protein 5; START domain containing 5; START domain-containing protein 5
Chromosome15
Map Location15q26
SummaryCholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for STARD5

Proteins

stAR-related lipid transfer protein 5
Refseq ID:NP_871629
Protein GI:32526915
UniProt ID:Q9NSY2
mRNA ID:NM_181900
Length:213
RefSeq Status:VALIDATED
MDPALAAQMSEAVAEKMLQYRRDTAGWKICREGNGVSVSWRPSVEFPGNLYRGEGIVYGTLEEVWDCVKPAVGGLRVKWDENVTGFEIIQSITDTLCVSR
TSTPSAAMKLISPRDFVDLVLVKRYEDGTISSNATHVEHPLCPPKPGFVRGFNHPCGCFCEPLPGEPTKTNLVTFFHTDLSGYLPQNVVDSFFPRSMTRF
YANLQKAVKQFHE