LMPD Database

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LMP000398

UniProt Annotations

Entry Information
Gene Nameapolipoprotein A-II
Protein EntryAPOA2_HUMAN
UniProt IDP02652
SpeciesHuman
Comments
Comment typeDescription
FunctionMay stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Mass SpectrometryMass=17166.2; Method=MALDI; Range=24-99; Note=Homodimer.; Evidence= ;
Mass SpectrometryMass=17252; Method=Electrospray; Range=24-100; Note=Homodimer, without methionine sulfoxide.; Evidence= ;
Mass SpectrometryMass=17269; Method=Electrospray; Range=24-100; Note=Homodimer, with 1 methionine sulfoxide, oxidation at Met-49.; Evidence= ;
Mass SpectrometryMass=17293.4; Method=MALDI; Range=24-100; Note=Heterodimer with truncated apolipoprotein A-II.; Evidence= ;
Mass SpectrometryMass=17421.3; Method=MALDI; Range=24-100; Note=Homodimer.; Evidence= ;
Mass SpectrometryMass=8578.3; Method=MALDI; Range=24-99; Evidence= ;
Mass SpectrometryMass=8701.2; Method=MALDI; Range=24-100; Evidence= ;
Mass SpectrometryMass=8823.4; Method=MALDI; Range=24-100; Note=Cysteinylated ApoA-II.; Evidence= ;
PolymorphismA homozygous transition at position 1 of intron 3 of APOA2 results in deficiency of apolipoprotein A-II, without significant influence either on lipid and lipoprotein profiles or on the occurrence of coronary artery disease [MIM
PtmApolipoprotein A-II is O-glycosylated.
PtmPhosphorylation sites are present in the extracellular medium.
SimilarityBelongs to the apolipoprotein A2 family.
Subcellular LocationSecreted.
SubunitHomodimer; disulfide-linked. Also forms a disulfide- linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP and NDRG1. {ECO
Tissue SpecificityPlasma; synthesized in the liver and intestine.
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA2";