LMPD Database

LMP000405

Record overview

LMPD ID	LMP000405
Gene ID	344
Species	Homo sapiens (Human)
Gene Name	apolipoprotein C-II
Gene Symbol	APOC2
Synonyms	APO-CII; APOC-II
Alternate names	apolipoprotein C-II; apolipoprotein C2
Chromosome	19
Map Location	19q13.2
Summary	This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
Orthologs	View orthologs and multiple alignments for APOC2

Proteins

apolipoprotein C-II precursor

Refseq ID:	NP_000474
Protein GI:	32130518
UniProt ID:	P02655
mRNA ID:	NM_000483
Length:	101
RefSeq Status:	REVIEWED

`MGTRLLPALFLVLLVLGFEVQGTQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGE E`

sig_peptide: 1..22
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02655.1)
calculated_mol_wt: 2387
peptide sequence: 
MGTRLLPALFLVLLVLGFEVQG

mat_peptide: 23..101
product: Apolipoprotein C-II
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02655.1)
calculated_mol_wt: 8915
peptide sequence: 
TQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE