LMPD Database

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LMP000424

UniProt Annotations

Entry Information
Gene Nameacylglycerol kinase
Protein EntryAGK_MOUSE
UniProt IDQ9ESW4
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ESW4-1; Sequence=Displayed; Name=2; IsoId=Q9ESW4-2; Sequence=VSP_020927; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=45 uM for diacylglycerol {ECO:0000269|PubMed:15252046}; Vmax=159 nmol/min/mg enzyme with dioeoylglycerol as substrate {ECO:0000269|PubMed:15252046};
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Catalytic ActivityATP + acylglycerol = ADP + acyl-sn-glycerol 3- phosphate.
CautionWas originally (PubMed:15252046) thought to have ceramide kinase activity. Such activity is however unlikely in vivo. {ECO:0000305|PubMed:15252046}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
FunctionLipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth. {ECO:0000269|PubMed:15252046}.
PathwayLipid metabolism; glycerolipid metabolism.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Subcellular LocationMitochondrion membrane {ECO:0000250}.
Tissue SpecificityUbiquitously expressed. {ECO:0000269|PubMed:15252046}.