LMPD Database

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LMP000448

UniProt Annotations

Entry Information
Gene Nameplatelet-activating factor receptor
Protein EntryPTAFR_HUMAN
UniProt IDP25105
SpeciesHuman
Comments
Comment typeDescription
FunctionReceptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. {ECO
InductionBy CSF2/GM-CSF, IL5/interleukin-5 and n-butyrate.
SimilarityBelongs to the G-protein coupled receptor 1 family.
Subcellular LocationCell membrane ; Multi-pass membrane protein .
SubunitInteracts with ARRB1.
Tissue SpecificityExpressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes. {ECO