LMPD Database

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LMP000546

Record overview

LMPD IDLMP000546
Gene ID66002
SpeciesHomo sapiens (Human)
Gene Namecytochrome P450, family 4, subfamily F, polypeptide 12
Gene SymbolCYP4F12
SynonymsCYPIVF12; F22329_1
Alternate namescytochrome P450 4F12; cytochrome P450, subfamily IVF, polypeptide 12
Chromosome19
Map Location19p13.1
EC Number1.14.14.1
SummaryThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
OrthologsView orthologs and multiple alignments for CYP4F12

Proteins

cytochrome P450 4F12
Refseq ID:NP_076433
Protein GI:333033782
UniProt ID:Q9HCS2
mRNA ID:NM_023944
Length:524
RefSeq Status:REVIEWED
MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFIV
LCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTL
DSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID
VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR
CCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRR
KLELIMRAEGGLWLRVEPLNVSLQ