LMPD Database

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LMP000727

Record overview

LMPD IDLMP000727
Gene ID10380
SpeciesHomo sapiens (Human)
Gene Name3'(2'), 5'-bisphosphate nucleotidase 1
Gene SymbolBPNT1
SynonymsHEL20; PIP
Chromosome1
Map Location1q41
EC Number3.1.3.7
SummaryBPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for BPNT1

Proteins

3'(2'),5'-bisphosphate nucleotidase 1 isoform 1
Refseq ID:NP_006076
Protein GI:116812595
UniProt ID:V9HWF9
mRNA ID:NM_006085
Length:308
RefSeq Status:VALIDATED
MASSNTVLMRLVASAYSIAQKAGMIVRRVIAEGDLGIVEKTCATDLQTKADRLAQMSICSSLARKFPKLTIIGEEDLPSEEVDQELIEDSQWEEILKQPC
PSQYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGVINQPYYNYEAGPDAVLGRTIWGVLGLGAFGFQLKEVPAGKHIITTTRSHSN
KLVTDCVAAMNPDAVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNVLQYHKDVKHMNSAGVLATLRNYDYYASRVPE
SIKNALVP
 
3'(2'),5'-bisphosphate nucleotidase 1 isoform 2
Refseq ID:NP_001273080
Protein GI:555290081
UniProt ID:O95861
mRNA ID:NM_001286151
Length:253
RefSeq Status:VALIDATED
MSICSSLARKFPKLTIIGEEDLPSEEVDQELIEDSQWEEILKQPCPSQYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGVINQPYY
NYEAGPDAVLGRTIWGVLGLGAFGFQLKEVPAGKHIITTTRSHSNKLVTDCVAAMNPDAVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVIL
HAVGGKLTDIHGNVLQYHKDVKHMNSAGVLATLRNYDYYASRVPESIKNALVP
 
3'(2'),5'-bisphosphate nucleotidase 1 isoform 2
Refseq ID:NP_001273078
Protein GI:555290116
UniProt ID:O95861
mRNA ID:NM_001286149
Length:253
RefSeq Status:VALIDATED
Protein sequence is identical to GI:555290081 (mRNA isoform)
 
3'(2'),5'-bisphosphate nucleotidase 1 isoform 3
Refseq ID:NP_001273079
Protein GI:555289990
UniProt ID:O95861
mRNA ID:NM_001286150
Length:272
RefSeq Status:VALIDATED
MASSNTVLMRLVASAYSIAQKAGMIVRRVIAEGDLGIVEKTCATDLQTKADRLAQMSICSSLARKFPKLTIIGEELVVWVDPLDGTKEYTEGLLDNVTVL
IGIAYEGKAIAGVINQPYYNYEAGPDAVLGRTIWGVLGLGAFGFQLKEVPAGKHIITTTRSHSNKLVTDCVAAMNPDAVLRVGGAGNKIIQLIEGKASAY
VFASPGCKKWDTCAPEVILHAVGGKLTDIHGNVLQYHKDVKHMNSAGVLATLRNYDYYASRVPESIKNALVP