LMPD Database

LMP000758

UniProt Annotations

Entry Information
Gene Nameplatelet-activating factor receptor
Protein EntryPTAFR_MOUSE
UniProt IDQ62035
SpeciesMouse
Comments
Comment typeDescription
FunctionReceptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system.
InductionBy lipopolysaccharide (LPS). {ECO:0000269|PubMed:8670084}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts with ARRB1. {ECO:0000250}.
Tissue SpecificityFound in a range of organs. Expressed most strongly in spleen, followed by skeletal muscle, lung and small intestine. Expressed at moderate levels in the heart. Expressed at relatively low levels in the brain, liver and kidney. {ECO:0000269|PubMed:8670084}.