LMPD Database

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LMP000769

UniProt Annotations

Entry Information
Gene NameGPI-anchored HDL-binding protein 1
Protein EntryQ9D1N2_MOUSE
UniProt IDQ9D1N2
SpeciesMouse
Comments
Comment typeDescription
Disruption PhenotypeMice manifest chylomicronemia, exhibiting a marked accumulation of chylomicrons in the plasma resulting in a milky plasma and plasma triglyceride levels as high as 5000 mg/dl. In Gpihbp1-deficient mice, LPL is mislocalized to the interstitial spaces surrounding myocytes and adipocytes.
FunctionPlays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen and across endothelial cells. {ECO:0000269|PubMed:17403372, ECO:0000269|PubMed:17620854, ECO:0000269|PubMed:20620994}.
PtmGlycosylation of Asn-76 is critical for cell surface localization and the binding of chylomicrons and lipoprotein lipase.
SimilarityContains 1 UPAR/Ly6 domain.
Subcellular LocationApical cell membrane; Lipid-anchor, GPI- anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell membrane; Peripheral membrane protein; Extracellular side.
SubunitBinds with high affinity to high-density lipoprotein (HDL). Binds to lipoprotein lipase (LPL), chylomicrons and APOA5. {ECO:0000250|UniProtKB:Q8IV16, ECO:0000269|PubMed:12496272, ECO:0000269|PubMed:17403372}.
Tissue SpecificityHighly expressed on the luminal surface of capillary endothelium in heart, adipose tissue and skeletal muscle. Not detected in capillaries of the brain. Expressed at lower levels in lung and liver. {ECO:0000269|PubMed:12496272, ECO:0000269|PubMed:17403372}.