LMPD Database

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LMP000889

UniProt Annotations

Entry Information
Gene Namecholine kinase alpha
Protein EntryCHKA_MOUSE
UniProt IDO54804
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CHETK-alpha2; IsoId=O54804-1; Sequence=Displayed; Name=2; Synonyms=CHETK-alpha1; IsoId=O54804-2; Sequence=VSP_009684;
Catalytic ActivityATP + choline = ADP + phosphocholine.
Catalytic ActivityATP + ethanolamine = ADP + O- phosphoethanolamine.
Disruption PhenotypeDeath at an early embryonic stage. Embryos die after 3 to 5 days of development. {ECO:0000269|PubMed:18029352}.
FunctionHas a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline (By similarity). {ECO:0000250}.
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.
PathwayPhospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
Sequence CautionSequence=AAH56758.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAA88154.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB29191.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAC34841.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAC35539.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
SimilarityBelongs to the choline/ethanolamine kinase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer, and heterodimer with CHKB. {ECO:0000269|PubMed:16490392}.
Tissue SpecificityExpressed ubiquitously with the highest level in testis.