LMPD Database

LMP001075

Record overview

LMPD IDLMP001075
Gene ID6342
SpeciesHomo sapiens (Human)
Gene Namesterol carrier protein 2
Gene SymbolSCP2
SynonymsNLTP; NSL-TP; SCP-2; SCP-CHI; SCP-X; SCPX
Chromosome1
Map Location1p32
EC Number2.3.1.176
SummaryThis gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]
OrthologsView orthologs and multiple alignments for SCP2

Proteins

non-specific lipid-transfer protein isoform 1 proprotein
Refseq ID:NP_002970
Protein GI:19923233
UniProt ID:Q59HG9
mRNA ID:NM_002979
Length:547
RefSeq Status:REVIEWED
MSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGKKALADAQIPYSAVDQACVGYVFGDSTCGQRAIYHSLGMTGIPIINVNNNCATGSTA
LFMARQLIQGGVAECVLALGFEKMSKGSLGIKFSDRTIPTDKHVDLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEHFAKIGWKNHKHSVNNPYSQF
QDEYSLDEVMASKEVFDFLTILQCCPTSDGAAAAILASEAFVQKYGLQSKAVEILAQEMMTDLPSSFEEKSIIKMVGFDMSKEAARKCYEKSGLTPNDID
VIELHDCFSTNELLTYEALGLCPEGQGATLVDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGIGGAVVV
TLYKMGFPEAASSFRTHQIEAVPTSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMA
DSDFLALMTGKMNPQSAFFQGKLKITGNMGLAMKLQNLQLQPGNAKL
 
mat_peptide: 21..143
product: sterol carrier protein 2 isoform 5
calculated_mol_wt: 13242
peptide sequence: 
SSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKLK
ITGNMGLAMKLQNLQLQPGNAKL mat_peptide: 18..140 product: non-specific lipid-transfer protein isoform 4 calculated_mol_wt: 13242 peptide sequence: SSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKLK
ITGNMGLAMKLQNLQLQPGNAKL mat_peptide: 21..59 product: sterol carrier protein 2 isoform 5 calculated_mol_wt: 4540 peptide sequence: SSASDGFKANLVFKEIEKKLEEIRRLTAQSQWLTQTSWL mat_peptide: 1..380 product: sterol carrier protein 2 3-oxoacyl-CoA thiolase isoform 7 calculated_mol_wt: 41114 peptide sequence: MSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGDSTCGQRAIYHSLGMTGIPIINVNNNCATGSTALFMARQLIQGGVAECVLALGFEKM
SKGSLGIKFSDRTIPTDKHVDLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEHFAKIGWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDFLTILQC
CPTSDGAAAAILASEAFVQKYGLQSKAVEILAQEMMTDLPSSFEEKSIIKMVGFDMSKEAARKCYEKSGLTPNDIDVIELHDCFSTNELLTYEALGLCPE
GQGATLVDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGIGGAVVVTLYK mat_peptide: 400..523 product: sterol carrier protein 2 isoform 7 calculated_mol_wt: 13344 peptide sequence: TSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKL
KITGNMGLAMKLQNLQLQPGNAKL mat_peptide: 1..360 product: sterol carrier protein 2 3-oxoacyl-CoA thiolase isoform 6 calculated_mol_wt: 39033 peptide sequence: MSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGKKALADAQIPYSAVDQACVGYVFGVAECVLALGFEKMSKGSLGIKFSDRTIPTDKHV
DLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEHFAKIGWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDFLTILQCCPTSDGAAAAILASEAFVQK
YGLQSKAVEILAQEMMTDLPSSFEEKSIIKMVGFDMSKEAARKCYEKSGLTPNDIDVIELHDCFSTNELLTYEALGLCPEGQGATLVDRGDNTYGGKWVI
NPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGIGGAVVVTLYK mat_peptide: 380..503 product: sterol carrier protein 2 isoform 6 calculated_mol_wt: 13344 peptide sequence: TSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKL
KITGNMGLAMKLQNLQLQPGNAKL mat_peptide: 1..323 product: sterol carrier protein 2 3-oxoacyl-CoA thiolase isoform 8 calculated_mol_wt: 34959 peptide sequence: MTGIPIINVNNNCATGSTALFMARQLIQGGVAECVLALGFEKMSKGSLGIKFSDRTIPTDKHVDLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEHF
AKIGWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDFLTILQCCPTSDGAAAAILASEAFVQKYGLQSKAVEILAQEMMTDLPSSFEEKSIIKMVGFDMS
KEAARKCYEKSGLTPNDIDVIELHDCFSTNELLTYEALGLCPEGQGATLVDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQV
PGAKVALQHNLGIGGAVVVTLYK mat_peptide: 343..466 product: sterol carrier protein 2 isoform 8 calculated_mol_wt: 13344 peptide sequence: TSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKL
KITGNMGLAMKLQNLQLQPGNAKL mat_peptide: 1..404 product: sterol carrier protein 2 3-oxoacyl-CoA thiolase isoform 1 calculated_mol_wt: 43611 peptide sequence: MSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGKKALADAQIPYSAVDQACVGYVFGDSTCGQRAIYHSLGMTGIPIINVNNNCATGSTA
LFMARQLIQGGVAECVLALGFEKMSKGSLGIKFSDRTIPTDKHVDLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEHFAKIGWKNHKHSVNNPYSQF
QDEYSLDEVMASKEVFDFLTILQCCPTSDGAAAAILASEAFVQKYGLQSKAVEILAQEMMTDLPSSFEEKSIIKMVGFDMSKEAARKCYEKSGLTPNDID
VIELHDCFSTNELLTYEALGLCPEGQGATLVDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGIGGAVVV
TLYK mat_peptide: 424..547 product: sterol carrier protein 2 isoform 1 calculated_mol_wt: 13344 peptide sequence: TSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKL
KITGNMGLAMKLQNLQLQPGNAKL
 
non-specific lipid-transfer protein isoform 2
Refseq ID:NP_001007099
Protein GI:55956775
UniProt ID:P22307
mRNA ID:NM_001007098
Length:322
RefSeq Status:REVIEWED
MSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGKKALADAQIPYSAVDQACVGYVFGVAECVLALGFEKMSKGSLGIKFSDRTIPTDKHV
DLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEHFAKIGWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDFLTILQCCPTSDGAAAAILASEAFVQK
YGLQSKAVEILAQEMMTDLPSSFEEKSIIKMVGFDMSKEAARKCYEKSGLTPNDIDVIELHDCFSTNELLTYEALGLCPEGQGATLVDRGDNTYGGKWVI
NPSGGLISKGHPLGATGGHSCS
 
non-specific lipid-transfer protein isoform 3 proprotein
Refseq ID:NP_001007251
Protein GI:55956781
UniProt ID:Q59HG9
mRNA ID:NM_001007250
Length:59
RefSeq Status:REVIEWED
MGFPEAASSFRTHQIEAVPTSSASDGFKANLVFKEIEKKLEEIRRLTAQSQWLTQTSWL
 
non-specific lipid-transfer protein isoform 4 proprotein
Refseq ID:NP_001007101
Protein GI:55956779
UniProt ID:Q59HG9
mRNA ID:NM_001007100
Length:140
RefSeq Status:REVIEWED
MGFPEAARTHQIEAVPTSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDFLAL
MTGKMNPQSAFFQGKLKITGNMGLAMKLQNLQLQPGNAKL
 
non-specific lipid-transfer protein isoform 5 proprotein
Refseq ID:NP_001007100
Protein GI:55956777
UniProt ID:Q59HG9
mRNA ID:NM_001007099
Length:143
RefSeq Status:REVIEWED
MGFPEAASSFRTHQIEAVPTSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDF
LALMTGKMNPQSAFFQGKLKITGNMGLAMKLQNLQLQPGNAKL
 
non-specific lipid-transfer protein isoform 6 proprotein
Refseq ID:NP_001180529
Protein GI:55956781
UniProt ID:Q59HG9
mRNA ID:NM_001193600
Length:59
RefSeq Status:REVIEWED
MGFPEAASSFRTHQIEAVPTSSASDGFKANLVFKEIEKKLEEIRRLTAQSQWLTQTSWL
 
non-specific lipid-transfer protein isoform 7 proprotein
Refseq ID:NP_001180528
Protein GI:55956781
UniProt ID:Q59HG9
mRNA ID:NM_001193599
Length:59
RefSeq Status:REVIEWED
MGFPEAASSFRTHQIEAVPTSSASDGFKANLVFKEIEKKLEEIRRLTAQSQWLTQTSWL
 
non-specific lipid-transfer protein isoform 8 proprotein
Refseq ID:NP_001180546
Protein GI:302344767
UniProt ID:Q59HG9
mRNA ID:NM_001193617
Length:466
RefSeq Status:REVIEWED
MTGIPIINVNNNCATGSTALFMARQLIQGGVAECVLALGFEKMSKGSLGIKFSDRTIPTDKHVDLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEHF
AKIGWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDFLTILQCCPTSDGAAAAILASEAFVQKYGLQSKAVEILAQEMMTDLPSSFEEKSIIKMVGFDMS
KEAARKCYEKSGLTPNDIDVIELHDCFSTNELLTYEALGLCPEGQGATLVDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQV
PGAKVALQHNLGIGGAVVVTLYKMGFPEAASSFRTHQIEAVPTSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNG
KGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKLKITGNMGLAMKLQNLQLQPGNAKL