LMPD Database

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LMP001124

Record overview

LMPD IDLMP001124
Gene ID2101
SpeciesHomo sapiens (Human)
Gene Nameestrogen-related receptor alpha
Gene SymbolESRRA
SynonymsERR1; ERRa; ERRalpha; ESRL1; NR3B1
Alternate namessteroid hormone receptor ERR1; ERR-alpha; estrogen receptor-like 1; estrogen-related nuclear receptor alpha; nuclear receptor subfamily 3 group B member 1
Chromosome11
Map Location11q13
SummaryThe protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
OrthologsView orthologs and multiple alignments for ESRRA

Proteins

steroid hormone receptor ERR1 isoform 1
Refseq ID:NP_004442
Protein GI:18860920
UniProt ID:P11474
mRNA ID:NM_004451
Length:423
RefSeq Status:REVIEWED
MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACK
AFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSH
LLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAA
GLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFY
GVKLEGKVPMHKLFLEMLEAMMD
 
steroid hormone receptor ERR1 isoform 1
Refseq ID:NP_001269379
Protein GI:540344536
UniProt ID:P11474
mRNA ID:NM_001282450
Length:423
RefSeq Status:REVIEWED
Protein sequence is identical to GI:18860920 (mRNA isoform)
 
steroid hormone receptor ERR1 isoform 2
Refseq ID:NP_001269380
Protein GI:540344538
UniProt ID:P11474
mRNA ID:NM_001282451
Length:422
RefSeq Status:REVIEWED
MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACK
AFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHL
LVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAG
LGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYG
VKLEGKVPMHKLFLEMLEAMMD