LMPD Database

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LMP001168

Record overview

LMPD IDLMP001168
Gene ID14081
SpeciesMus musculus(Mouse)
Gene Nameacyl-CoA synthetase long-chain family member 1
Gene SymbolAcsl1
SynonymsAcas; Acas1; Acs; FACS; Facl2; LACS 1; LACS1
Alternate nameslong-chain-fatty-acid--CoA ligase 1; acetate-CoA ligase; acetyl-CoA synthetase; long-chain acyl-CoA synthetase 1; fatty acid Coenzyme A ligase, long chain 2; acetyl-Coenzyme A synthetase 1 (ADP forming)
Chromosome8
Map Location8|8 B2
EC Number6.2.1.3
SummaryThe protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
OrthologsView orthologs and multiple alignments for Acsl1

Proteins

long-chain-fatty-acid--CoA ligase 1
Refseq ID:NP_032007
Protein GI:31560705
UniProt ID:P41216
mRNA ID:NM_007981
Length:699
RefSeq Status:REVIEWED
MEVHELFRYFRMPELIDIRQYVRTLPTNTLMGFGAFAALTTFWYATRPKALKPPCDLSMQSVEIAGTTDGIRRSAVLEDDKLLVYYYDDVRTMYDGFQRG
IQVSNNGPCLGSRKPNQPYEWISYKEVAELAECIGSGLIQKGFKPCSEQFIGLFSQNRPEWVIVEQGCFSYSMVVVPLYDTLGADAITYIVNKAELSVIF
ADKPEKAKLLLEGVENKLTPCLKIIVIMDSYGSDLVERGKKCGVEIISLKALEDLGRVNRVKPKPPEPEDLAIICFTSGTTGNPKGAMITHQNIINDCSG
FIKATESAFIASTDDVLISFLPLAHMFETVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTIFPVVPRLLNRMFDRIFGQANTSLKRWLLDFASKRKEA
ELRSGIVRNNSLWDKLIFHKIQSSLGGKVRLMITGAAPVSATVLTFLRTALGCQFYEGYGQTECTAGCCLSLPGDWTAGHVGAPMPCNYVKLVDVEEMNY
LASKGEGEVCVKGANVFKGYLKDPARTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYLRSEAVAQVFVHGESLQAFLIA
VVVPDVESLPSWAQKRGLQGSFEELCRNKDINKAILDDLLKLGKEAGLKPFEQVKGIAVHPELFSIDNGLLTPTLKAKRPELRNYFRSQIDELYATIKI