LMPD Database

LMP001184

Record overview

LMPD IDLMP001184
Gene ID8435
SpeciesHomo sapiens (Human)
Gene Namesterol O-acyltransferase 2
Gene SymbolSOAT2
SynonymsACACT2; ACAT2; ARGP2
Alternate namessterol O-acyltransferase 2; ACAT-2; cholesterol acyltransferase 2; acyl-CoA:cholesterol acyltransferase 2; acyl Co-A: cholesterol acyltransferase 2; acyl coenzyme A:cholesterol acyltransferase 2; acyl-coenzyme A:cholesterol acyltransferase 2
Chromosome12
Map Location12q13.13
EC Number2.3.1.26
SummarySummary:This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SOAT2

Proteins

sterol O-acyltransferase 2
Refseq ID:NP_003569
Protein GI:4507147
UniProt ID:O75908
mRNA ID:NM_003578
Length:522
RefSeq Status:REVIEWED
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGK
QKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLG
CALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN
FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHD
WLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARR
HCPLPQATFWGLVTPRSWSCHT