LMPD Database

LMP001438

Record overview

LMPD IDLMP001438
Gene ID27329
SpeciesHomo sapiens (Human)
Gene Nameangiopoietin-like 3
Gene SymbolANGPTL3
SynonymsANG-5; ANGPT5; ANL3; FHBL2
Alternate namesangiopoietin-related protein 3; angiopoietin 5
Chromosome1
Map Location1p31.3
SummaryThis gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]
OrthologsView orthologs and multiple alignments for ANGPTL3

Proteins

angiopoietin-related protein 3 preproprotein
Refseq ID:NP_055310
Protein GI:7656888
UniProt ID:Q9Y5C1
mRNA ID:NM_014495
Length:460
RefSeq Status:REVIEWED
MFTIKLLLFIVPLVISSRIDQDNSSFDSLSPEPKSRFAMLDDVKILANGLLQLGHGLKDFVHKTKGQINDIFQKLNIFDQSFYDLSLQTSEIKEEEKELR
RTTYKLQVKNEEVKNMSLELNSKLESLLEEKILLQQKVKYLEEQLTNLIQNQPETPEHPEVTSLKTFVEKQDNSIKDLLQTVEDQYKQLNQQHSQIKEIE
NQLRRTSIQEPTEISLSSKPRAPRTTPFLQLNEIRNVKHDGIPAECTTIYNRGEHTSGMYAIRPSNSQVFHVYCDVISGSPWTLIQHRIDGSQNFNETWE
NYKYGFGRLDGEFWLGLEKIYSIVKQSNYVLRIELEDWKDNKHYIEYSFYLGNHETNYTLHLVAITGNVPNAIPENKDLVFSTWDHKAKGHFNCPEGYSG
GWWWHDECGENNLNGKYNKPRAKSKPERRRGLSWKSQNGRLYSIKSTKMLIHPTDSESFE
 
sig_peptide: 1..16
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1847
peptide sequence: 
MFTIKLLLFIVPLVIS

mat_peptide: 17..224
product: N-terminal coiled-coil domain
calculated_mol_wt: 24281
peptide sequence: 
SRIDQDNSSFDSLSPEPKSRFAMLDDVKILANGLLQLGHGLKDFVHKTKGQINDIFQKLNIFDQSFYDLSLQTSEIKEEEKELRRTTYKLQVKNEEVKNM
SLELNSKLESLLEEKILLQQKVKYLEEQLTNLIQNQPETPEHPEVTSLKTFVEKQDNSIKDLLQTVEDQYKQLNQQHSQIKEIENQLRRTSIQEPTEISL
SSKPRAPR mat_peptide: 225..460 product: C-terminal fibrinogen domain note: The cleavage site was determined in PMID: 12909640. calculated_mol_wt: 27545 peptide sequence: TTPFLQLNEIRNVKHDGIPAECTTIYNRGEHTSGMYAIRPSNSQVFHVYCDVISGSPWTLIQHRIDGSQNFNETWENYKYGFGRLDGEFWLGLEKIYSIV
KQSNYVLRIELEDWKDNKHYIEYSFYLGNHETNYTLHLVAITGNVPNAIPENKDLVFSTWDHKAKGHFNCPEGYSGGWWWHDECGENNLNGKYNKPRAKS
KPERRRGLSWKSQNGRLYSIKSTKMLIHPTDSESFE