LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001531

Record overview

LMPD IDLMP001531
Gene ID134429
SpeciesHomo sapiens (Human)
Gene NameStAR-related lipid transfer (START) domain containing 4
Gene SymbolSTARD4
Synonyms-
Alternate namesstAR-related lipid transfer protein 4; START domain-containing protein 4; START domain containing 4 sterol-regulated; START domain containing 4, sterol regulated
Chromosome5
Map Location5q22.1
SummaryCholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for STARD4

Proteins

stAR-related lipid transfer protein 4
Refseq ID:NP_631903
Protein GI:21040247
UniProt ID:Q96DR4
mRNA ID:NM_139164
Length:205
RefSeq Status:PROVISIONAL
MEGLSDVASFATKLKNTLIQYHSIEEDKWRVAKKTKDVTVWRKPSEEFNGYLYKAQGVIDDLVYSIIDHIRPGPCRLDWDSLMTSLDILENFEENCCVMR
YTTAGQLWNIISPREFVDFSYTVGYKEGLLSCGISLDWDEKRPEFVRGYNHPCGWFCVPLKDNPNQSLLTGYIQTDLRGMIPQSAVDTAMASTLTNFYGD
LRKAL