LMPD Database

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LMP001920

Record overview

LMPD IDLMP001920
Gene ID147323
SpeciesHomo sapiens (Human)
Gene NameStAR-related lipid transfer (START) domain containing 6
Gene SymbolSTARD6
Synonyms-
Alternate namesstAR-related lipid transfer protein 6; START domain containing 6; START domain-containing protein 6
Chromosome18
Map Location18q21.2
SummaryCholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for STARD6

Proteins

stAR-related lipid transfer protein 6
Refseq ID:NP_631910
Protein GI:21040261
UniProt ID:P59095
mRNA ID:NM_139171
Length:220
RefSeq Status:PROVISIONAL
MDFKAIAQQTAQEVLGYNRDTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGIIPESPAKLSDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQS
FAVGSISPRDFIDLVYIKRYEGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEMRGKLSPSIIEKTMPSNLVNFILNAK
DGIKAHRTPSRRGFHHNSHS