LMPD Database

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LMP002215

UniProt Annotations

Entry Information
Gene Namelipopolysaccharide binding protein
Protein EntryLBP_HUMAN
UniProt IDP18428
SpeciesHuman
Comments
Comment typeDescription
FunctionPlays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
InteractionQ13162:PRDX4; NbExp=4; IntAct=EBI-3927059, EBI-2211957;
SimilarityBelongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Subcellular LocationSecreted .
SubunitWhen bound to LPS, interacts (via C-terminus) with soluble CD14.
Tissue SpecificityDetected in blood serum (at protein level).