LMPD Database

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LMP002234

UniProt Annotations

Entry Information
Gene Namelipoprotein lipase
Protein EntryLIPL_HUMAN
UniProt IDP06858
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate.
DiseaseLipoprotein lipase deficiency (LPL deficiency) [MIM
FunctionThe primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity).
PtmTyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
SimilarityBelongs to the AB hydrolase superfamily. Lipase family.
SimilarityContains 1 PLAT domain. {ECO
Subcellular LocationCell membrane ; Lipid-anchor, GPI-anchor {ECO
SubunitHomodimer (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids. Interacts with GPIHBP1. {ECO
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LPL";
Web ResourceName=Wikipedia; Note=Lipoprotein lipase entry; URL="http://en.wikipedia.org/wiki/Lipoprotein_lipase";