LMPD Database

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LMP002250

UniProt Annotations

Entry Information
Gene Nameenoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
Protein EntryECHP_MOUSE
UniProt IDQ9DBM2
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O.
Catalytic Activity(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA.
Catalytic Activity(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
Enzyme RegulationEnzyme activity enhanced by acetylation. {ECO:0000250}.
PathwayLipid metabolism; fatty acid beta-oxidation.
PtmAcetylated, leading to enhanced enzyme activity. Acetylation is enhanced by up to 80% after treatment either with trichostin A (TCA) or with nicotinamide (NAM) with highest increase on Lys-344. Acetylation and enzyme activity increased by about 1.5% on addition of fatty acids (By similarity). {ECO:0000250}.
SimilarityIn the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family. {ECO:0000305}.
SimilarityIn the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular LocationPeroxisome {ECO:0000250}.
SubunitMonomer. {ECO:0000250}.