LMPD Database

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LMP002304

UniProt Annotations

Entry Information
Gene Name3-hydroxy-3-methylglutaryl-Coenzyme A lyase
Protein EntryHMGCL_MOUSE
UniProt IDP38060
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity(S)-3-hydroxy-3-methylglutaryl-CoA = acetyl- CoA + acetoacetate. {ECO:0000255|PROSITE-ProRule:PRU10115}.
FunctionKey enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism (By similarity). {ECO:0000250}.
PathwayMetabolic intermediate metabolism; (S)-3-hydroxy-3- methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3- methylglutaryl-CoA: step 1/1.
SimilarityBelongs to the HMG-CoA lyase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:7527399}. Peroxisome {ECO:0000269|PubMed:7527399}. Note=Unprocessed form is peroxisomal.
SubunitHomodimer; disulfide-linked. Can also form homotetramers. {ECO:0000250}.