LMPD Database

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LMP002504

Record overview

LMPD IDLMP002504
Gene ID7368
SpeciesHomo sapiens (Human)
Gene NameUDP glycosyltransferase 8
Gene SymbolUGT8
SynonymsCGT; UGT4
Alternate names2-hydroxyacylsphingosine 1-beta-galactosyltransferase; cerebroside synthase; ceramide UDP-galactosyltransferase; uridine diphosphate glycosyltransferase 8; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase
Chromosome4
Map Location4q26
EC Number2.4.1.45
SummaryThe protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
OrthologsView orthologs and multiple alignments for UGT8

Proteins

2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor
Refseq ID:NP_001121646
Protein GI:189491660
UniProt ID:Q16880
mRNA ID:NM_001128174
Length:541
RefSeq Status:VALIDATED
MKSYTPYFILLWSAVGIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTA
IELFDILDHYTKNCDLMVGNHALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVY
LISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYL
SEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLE
WKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIY
RKIKSLWSRNKHSTVNGHYHNGILNGKYKRNGHIKHEKKVK
 
2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor
Refseq ID:NP_003351
Protein GI:40254471
UniProt ID:Q16880
mRNA ID:NM_003360
Length:541
RefSeq Status:VALIDATED
Protein sequence is identical to GI:189491660 (mRNA isoform)
 
sig_peptide: 1..20
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q16880.2)
calculated_mol_wt: 2260
peptide sequence: 
MKSYTPYFILLWSAVGIAKA

mat_peptide: 21..541
product: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q16880.2)
calculated_mol_wt: 59214
peptide sequence: 
AKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGN
HALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQ
KYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVI
WRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNP
SYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYH
NGILNGKYKRNGHIKHEKKVK

sig_peptide: 1..20
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q16880.2)
calculated_mol_wt: 2260
peptide sequence: 
MKSYTPYFILLWSAVGIAKA

mat_peptide: 21..541
product: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q16880.2)
calculated_mol_wt: 59214
peptide sequence: 
AKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGN
HALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQ
KYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVI
WRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNP
SYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYH
NGILNGKYKRNGHIKHEKKVK