LMPD Database

LMP002740

UniProt Annotations

Entry Information
Gene Nameceramide kinase
Protein EntryCERK1_HUMAN
UniProt IDQ8TCT0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TCT0-1; Sequence=Displayed; Name=2; IsoId=Q8TCT0-2; Sequence=VSP_056944; Note=No experimental confirmation available;
Biophysicochemical PropertiespH dependence: Optimum pH is 6.0-7.5.;
Catalytic ActivityATP + ceramide = ADP + ceramide 1-phosphate.
CofactorName=Ca(2+); Xref=ChEBI
CofactorName=Mg(2+); Xref=ChEBI
Enzyme RegulationInhibited by sulfatide.
FunctionCatalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.
SimilarityContains 1 DAGKc domain. {ECO
Subcellular LocationCytoplasm . Membrane ; Peripheral membrane protein .
Tissue SpecificityHigh level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.