LMPD Database

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LMP002838

Record overview

LMPD IDLMP002838
Gene ID5660
SpeciesHomo sapiens (Human)
Gene Nameprosaposin
Gene SymbolPSAP
SynonymsGLBA; SAP1
Alternate namesprosaposin; proactivator polypeptide; sphingolipid activator protein-1
Chromosome10
Map Location10q21-q22
SummaryThis gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PSAP

Proteins

prosaposin isoform a preproprotein
Refseq ID:NP_002769
Protein GI:11386147
UniProt ID:P07602
mRNA ID:NM_002778
Length:524
RefSeq Status:REVIEWED
MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKP
NMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQD
CIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVE
PIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHV
TQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPS
YWCQNTETAAQCNAVEHCKRHVWN
 
sig_peptide: 1..16
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1638
peptide sequence: 
MYALFLLASLLGAALA

mat_peptide: 60..142
product: saposin A
note: protein A
calculated_mol_wt: 9108
peptide sequence: 
SLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQ

mat_peptide: 195..276
product: saposin B
note: sphingolipid activator protein 1, SAP-1, cerebroside sulfate activator, CSAct, dispersin, sulfatide/GM1 activator
calculated_mol_wt: 9247
peptide sequence: 
GDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQDQQPKEICALVGFCDE

mat_peptide: 314..394
product: saposin C
note: co-beta-glucosidase, A1 activator, glucosylceramidase activator, sphingolipid activator protein 2, SAP-2
calculated_mol_wt: 9051
peptide sequence: 
SDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGT

mat_peptide: 408..489
product: saposin D
note: protein C, component C
calculated_mol_wt: 9127
peptide sequence: 
DGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAH

sig_peptide: 1..16
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1638
peptide sequence: 
MYALFLLASLLGAALA

mat_peptide: 60..142
product: saposin A
note: protein A
calculated_mol_wt: 9108
peptide sequence: 
SLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQ

mat_peptide: 195..275
product: saposin B
note: sphingolipid activator protein 1, SAP-1, cerebroside sulfate activator, CSAct, dispersin, sulfatide/GM1 activator
calculated_mol_wt: 9119
peptide sequence: 
GDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMDQQPKEICALVGFCDE

mat_peptide: 313..393
product: saposin C
note: co-beta-glucosidase, A1 activator, glucosylceramidase activator, sphingolipid activator protein 2, SAP-2
calculated_mol_wt: 9051
peptide sequence: 
SDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGT

mat_peptide: 406..488
product: saposin D
note: protein C, component C
calculated_mol_wt: 9255
peptide sequence: 
KDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAH

sig_peptide: 1..16
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1638
peptide sequence: 
MYALFLLASLLGAALA

mat_peptide: 60..142
product: saposin A
note: protein A
calculated_mol_wt: 9108
peptide sequence: 
SLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQ

mat_peptide: 195..273
product: saposin B
note: sphingolipid activator protein 1, SAP-1, cerebroside sulfate activator, CSAct, dispersin, sulfatide/GM1 activator
calculated_mol_wt: 8875
peptide sequence: 
GDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDE

mat_peptide: 311..391
product: saposin C
note: co-beta-glucosidase, A1 activator, glucosylceramidase activator, sphingolipid activator protein 2, SAP-2
calculated_mol_wt: 9051
peptide sequence: 
SDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGT

mat_peptide: 405..486
product: saposin D
note: protein C, component C
calculated_mol_wt: 9127
peptide sequence: 
DGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAH
 
prosaposin isoform b preproprotein
Refseq ID:NP_001035930
Protein GI:110224476
UniProt ID:P07602
mRNA ID:NM_001042465
Length:527
RefSeq Status:REVIEWED
MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKP
NMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQD
CIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQDQQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALE
LVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALT
VHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIW
GPSYWCQNTETAAQCNAVEHCKRHVWN
 
prosaposin isoform c preproprotein
Refseq ID:NP_001035931
Protein GI:110224476
UniProt ID:P07602
mRNA ID:NM_001042466
Length:527
RefSeq Status:REVIEWED
MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKP
NMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQD
CIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQDQQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALE
LVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALT
VHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIW
GPSYWCQNTETAAQCNAVEHCKRHVWN