LMPD Database

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LMP002842

UniProt Annotations

Entry Information
Gene Nameceramide kinase
Protein EntryCERK1_MOUSE
UniProt IDQ8K4Q7
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + ceramide = ADP + ceramide 1-phosphate.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Developmental StageHighly expressed at 7 dpc and decreases rapidly thereafter.
FunctionCatalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (By similarity). {ECO:0000250}.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Subcellular LocationCytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue SpecificityHigh level expression in heart, brain and testis; low expression in spleen, liver and lung; not detected in skeletal muscle.