LMPD Database

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LMP003729

Record overview

LMPD IDLMP003729
Gene ID338328
SpeciesHomo sapiens (Human)
Gene Nameglycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Gene SymbolGPIHBP1
SynonymsGPI-HBP1; HYPL1D
Alternate namesglycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; endothelial cell LPL transporter; GPI-anchored HDL-binding protein 1; GPI anchored high density lipoprotein binding protein 1
Chromosome8
Map Location8q24.3
SummaryThis gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
OrthologsView orthologs and multiple alignments for GPIHBP1

Proteins

glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 1 precursor
Refseq ID:NP_835466
Protein GI:613410183
UniProt ID:Q8IV16
mRNA ID:NM_178172
Length:184
RefSeq Status:REVIEWED
MKALGAVLLALLLFGRPGRGQTQQEEEEEDEDHGPDDYDEEDEDEVEEEETNRLPGGRSRVLLRCYTCKSLPRDERCNLTQNCSHGQTCTTLIAHGNTES
GLLTTHSTWCTDSCQPITKTVEGTQVTMTCCQSSLCNVPPWQSSRVQDPTGKGAGGPRGSSETVGAALLLNLLAGLGAMGARRP
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2054
peptide sequence: 
MKALGAVLLALLLFGRPGRG

sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2054
peptide sequence: 
MKALGAVLLALLLFGRPGRG

mat_peptide: 21..151
product: Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q8IV16.2)
calculated_mol_wt: 14713
peptide sequence: 
QTQQEEEEEDEDHGPDDYDEEDEDEVEEEETNRLPGGRSRVLLRCYTCKSLPRDERCNLTQNCSHGQTCTTLIAHGNTESGLLTTHSTWCTDSCQPITKT
VEGTQVTMTCCQSSLCNVPPWQSSRVQDPTG