LMPD Database

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LMP003856

Record overview

LMPD IDLMP003856
Gene ID79644
SpeciesHomo sapiens (Human)
Gene Namesteroid 5 alpha-reductase 3
Gene SymbolSRD5A3
SynonymsCDG1P; CDG1Q; KRIZI; SRD5A2L; SRD5A2L1
Alternate namespolyprenol reductase; S5AR 3; SR type 3; probable polyprenol reductase; 3-oxo-5-alpha-steroid 4-dehydrogenase 3
Chromosome4
Map Location4q12
EC Number1.3.1.94
SummaryThe protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq. [provided by RefSeq, Mar 2011]
OrthologsView orthologs and multiple alignments for SRD5A3

Proteins

polyprenol reductase
Refseq ID:NP_078868
Protein GI:13375785
UniProt ID:Q9H8P0
mRNA ID:NM_024592
Length:318
RefSeq Status:REVIEWED
MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEPSRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFL
GAPFPSWLHGLLRILGAAQFQGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQVPMDGRNAYITGKNLLMQAR
WFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK
SKFVSYPKHRKAFLPFLF