LMPD Database

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LMP003908

UniProt Annotations

Entry Information
Gene Nameparaoxonase 1
Protein EntryPON1_MOUSE
UniProt IDP52430
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAn aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol. {ECO:0000269|PubMed:15963993}.
Catalytic ActivityAn N-acyl-L-homoserine lactone + H(2)O = an N- acyl-L-homoserine. {ECO:0000269|PubMed:15963993}.
Catalytic ActivityA phenyl acetate + H(2)O = a phenol + acetate. {ECO:0000269|PubMed:15963993}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 2 calcium ions per subunit. {ECO:0000250};
FunctionHydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification (By similarity). {ECO:0000250}.
MiscellaneousThe preferential association of PON1 with HDL is mediated in part by its signal peptide, by binding phospholipids directly, rather than binding apo AI. The retained signal peptide may allow transfer of the protein between phospholipid surfaces (By similarity). {ECO:0000250}.
PtmThe signal sequence is not cleaved. {ECO:0000250}.
SimilarityBelongs to the paraoxonase family. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space.
SubunitHomodimer. Interacts with CLU (By similarity). {ECO:0000250}.
Tissue SpecificityPlasma, liver, kidney, heart, brain, small intestine and lung. In the plasma, associated with HDL.