LMPD Database

LMP004483

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase bubblegum family member 2
Protein EntryACBG2_MOUSE
UniProt IDQ2XU92
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
FunctionMediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis (By similarity). {ECO:0000250}.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm. Membrane; Peripheral membrane protein.
Tissue SpecificityTestis- and brainstem-specific. Expressed in pubertal and adult testis. Enriched in germ cells and Sertoli cells while present at a lower level in Leydig cells. Present in testicular Sertoli cells and large motoneurons in the medulla oblongata and cervical spinal cord (at protein level). {ECO:0000269|PubMed:16371355, ECO:0000269|PubMed:16762313}.