LMPD Database

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LMP004643

Record overview

LMPD IDLMP004643
Gene ID51449
SpeciesHomo sapiens (Human)
Gene Nameprenylcysteine oxidase 1
Gene SymbolPCYOX1
SynonymsPCL1
Alternate namesprenylcysteine oxidase 1; prenylcysteine lyase
Chromosome2
Map Location2p13.3
EC Number1.8.3.5
SummaryPrenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for PCYOX1

Proteins

prenylcysteine oxidase 1 precursor
Refseq ID:NP_057381
Protein GI:166795301
UniProt ID:Q9UHG3
mRNA ID:NM_016297
Length:505
RefSeq Status:VALIDATED
MGRVVAELVSSLLGLWLLLCSCGCPEGAELRAPPDKIAIIGAGIGGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGSVIHPLNLHMK
RFVKDLGLSAVQASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRIYRYQSHDYAFSSVEKLLHALGGDDFLGMLNRTLL
ETLQKAGFSEKFLNEMIAPVMRVNYGQSTDINAFVGAVSLSCSDSGLWAVEGGNKLVCSGLLQASKSNLISGSVMYIEEKTKTKYTGNPTKMYEVVYQIG
TETRSDFYDIVLVATPLNRKMSNITFLNFDPPIEEFHQYYQHIVTTLVKGELNTSIFSSRPIDKFGLNTVLTTDNSDLFINSIGIVPSVREKEDPEPSTD
GTYVWKIFSQETLTKAQILKLFLSYDYAVKKPWLAYPHYKPPEKCPSIILHDRLYYLNGIECAASAMEMSAIAAHNAALLAYHRWNGHTDMIDQDGLYEK
LKTEL
 
sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2806
peptide sequence: 
MGRVVAELVSSLLGLWLLLCSCGCPEG

mat_peptide: 28..505
product: Prenylcysteine oxidase 1
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9UHG3.3)
calculated_mol_wt: 53852
peptide sequence: 
AELRAPPDKIAIIGAGIGGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGSVIHPLNLHMKRFVKDLGLSAVQASGGLLGIYNGETLV
FEESNWFIINVIKLVWRYGFQSLRMHMWVEDVLDKFMRIYRYQSHDYAFSSVEKLLHALGGDDFLGMLNRTLLETLQKAGFSEKFLNEMIAPVMRVNYGQ
STDINAFVGAVSLSCSDSGLWAVEGGNKLVCSGLLQASKSNLISGSVMYIEEKTKTKYTGNPTKMYEVVYQIGTETRSDFYDIVLVATPLNRKMSNITFL
NFDPPIEEFHQYYQHIVTTLVKGELNTSIFSSRPIDKFGLNTVLTTDNSDLFINSIGIVPSVREKEDPEPSTDGTYVWKIFSQETLTKAQILKLFLSYDY
AVKKPWLAYPHYKPPEKCPSIILHDRLYYLNGIECAASAMEMSAIAAHNAALLAYHRWNGHTDMIDQDGLYEKLKTEL