LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP006552

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase bubblegum family member 1
Protein EntryACBG1_MOUSE
UniProt IDQ99PU5
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. {ECO:0000269|PubMed:11112418, ECO:0000269|PubMed:14516277}.
Developmental StageFirst detected on embryonic day 18 and increases steadily towards adulthood. {ECO:0000269|PubMed:14516277}.
FunctionMediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (By similarity). {ECO:0000250}.
Sequence CautionSequence=BAC97989.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Cytoplasmic vesicle. Microsome. Endoplasmic reticulum.
Tissue SpecificityMainly expressed in brain. Also expressed in adrenal gland and testis. In brain, it is present in cerebral cortical and cerebellar neurons and in steroidogenic cells of the adrenal gland, testis and ovary (at protein level). {ECO:0000269|PubMed:11112418, ECO:0000269|PubMed:12975357, ECO:0000269|PubMed:14516277, ECO:0000269|PubMed:16469493}.