LMPD Database

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LMP006635

UniProt Annotations

Entry Information
Gene Namedelta(4)-desaturase, sphingolipid 2
Protein EntryQ6QHC5_HUMAN
UniProt IDQ6QHC5
SpeciesHuman
Comments
Comment typeDescription
FunctionBifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase.
InductionUp-regulated during keratinocyte differentiation. Not expressed at day 0 or day 3 after differentiation, detected on day 6 and increases by day 9.
PathwayMembrane lipid metabolism; sphingolipid biosynthesis.
SimilarityBelongs to the fatty acid desaturase family. DEGS subfamily.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityHighly expressed in skin, intestine and kidney.