LMPD Database


UniProt Annotations

Entry Information
Gene Namelipase, endothelial
Protein EntryLIPE_HUMAN
UniProt IDQ9Y5X9
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5X9-1; Sequence=Displayed; Name=2; IsoId=Q9Y5X9-2; Sequence=VSP_013302, VSP_013303; Note=No experimental confirmation available.;
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Enzyme RegulationInhibited by serum.
FunctionHas phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.
MiscellaneousIt is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a characteristic that distinguishes it from other members of the family. However, this protein is also expressed in other cell types.
SimilarityBelongs to the AB hydrolase superfamily. Lipase family.
SimilarityContains 1 PLAT domain. {ECO
Subcellular LocationSecreted.
SubunitHead to tail homodimer.
Tissue SpecificityHigh level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosarcoma cell lines. Not detected in heart, brain and muscle.