LMPD Database

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LMP007150

UniProt Annotations

Entry Information
Gene Namebifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2
Protein EntryFOX2_YEAST
UniProt IDQ02207
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O.
Catalytic Activity(R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
DomainContains two SDR domains.
FunctionSecond trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase- epimerase activities. Converts trans-2-enoyl-CoA via D-3- hydroxyacyl-CoA to 3-ketoacyl-CoA.
PathwayLipid metabolism; fatty acid beta-oxidation.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
SimilarityContains 1 MaoC-like domain
SimilarityContains 1 MaoC-like domain. {ECO:0000305}.
Subcellular LocationPeroxisome.
SubunitMonomer
SubunitMonomer. {ECO:0000250}.