LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP007307

UniProt Annotations

Entry Information
Gene Namelong-chain fatty acid-CoA ligase FAA1
Protein EntryLCF1_YEAST
UniProt IDP30624
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesTemperature dependence: Optimum temperature is 30 degrees Celsius.;
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
FunctionEsterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities.
MiscellaneousPresent with 7470 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.