LMPD Database

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LMP007573

UniProt Annotations

Entry Information
Gene Name3-oxoacyl-[acyl-carrier-protein] reductase
Protein EntryFABG_ECOLI
UniProt IDP0AEK2
SpeciesE. coli
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is between 6.0 and 7.0. {ECO:0000269|PubMed:4381013};
Catalytic Activity(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH. {ECO:0000269|PubMed:8631920}.
Enzyme RegulationInhibited by cinnamic acid derivatives. {ECO:0000269|PubMed:18977209}.
FunctionCatalyzes the NADPH-dependent reduction of beta- ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. {ECO:0000269|PubMed:14996818, ECO:0000269|PubMed:8631920}.
MiscellaneousCalcium ions stabilize the structure, and may inhibit FabG activity by obstructing access to the active site.
PathwayLipid metabolism; fatty acid biosynthesis.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
SubunitHomotetramer. {ECO:0000269|PubMed:11669613, ECO:0000269|PubMed:15016358}.