LMPD Database

LMP007589

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase (long-chain-fatty-acid--CoA ligase)
Protein EntryLCFA_ECOLI
UniProt IDP69451
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
FunctionCatalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.
MiscellaneousActivity is the highest with fatty acid substrates of > 10 carbon atoms.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Partially membrane-associated. {ECO:0000250}.
SubunitHomodimer. {ECO:0000305}.