LMPD Database

LMP007712

UniProt Annotations

Entry Information
Gene Namebeta-ketoacyl-CoA thiolase, anaerobic, subunit
Protein EntryFADI_ECOLI
UniProt IDP76503
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
FunctionCatalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long- chain fatty acids. {ECO:0000269|PubMed:12270828, ECO:0000269|PubMed:12535077}.
InductionUnlike the aerobic pathway, the anaerobic pathway is not strongly repressed by FadR regulatory protein.
PathwayLipid metabolism; fatty acid beta-oxidation.
SimilarityBelongs to the thiolase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHeterotetramer of two alpha chains (FadJ) and two beta chains (FadI). {ECO:0000250}.