LMPD Database

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LMP008928

UniProt Annotations

Entry Information
Gene Nameeasily shocked
Protein EntryEAS_DROME
UniProt IDX2JFQ7
SpeciesDrosophila
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=E; IsoId=P54352-1; Sequence=Displayed; Name=A; Synonyms=B, C, H, I; IsoId=P54352-2; Sequence=VSP_001068; Name=G; IsoId=P54352-4; Sequence=VSP_053946, VSP_053947, VSP_053948; Note=No experimental confirmation available.; Name=F; IsoId=P54352-5; Sequence=VSP_053947, VSP_053948; Note=No experimental confirmation available.;
Catalytic ActivityATP + ethanolamine = ADP + O- phosphoethanolamine.
Disruption PhenotypeBang sensitive phenotype; induction of paralysis with electrical stimulation results in a brief seizure, followed by a failure of the muscles to respond to giant fiber stimulation. This is due to an excitability defect caused by altered membrane phospholipid composition. {ECO:0000269|PubMed:7923374}.
FunctionHighly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. {ECO:0000269|PubMed:7923374}.
PathwayPhospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. {ECO:0000269|PubMed:7923374}.
Sequence CautionSequence=ABE73230.1; Type=Frameshift; Positions=152; Evidence={ECO:0000305}; Sequence=ABE73230.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=ACV91649.1; Type=Frameshift; Positions=152, 215; Evidence={ECO:0000305};
SimilarityBelongs to the choline/ethanolamine kinase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.