LMPD Database

LMP010567

UniProt Annotations

Entry Information
Gene Namelong-chain acyl-CoA synthetase 7
Protein EntryLACS7_ARATH
UniProt IDQ8LKS5
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. {ECO:0000269|PubMed:12177484, ECO:0000269|PubMed:12366803}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Developmental StageInduced during seed germination. {ECO:0000269|PubMed:12366803}.
Disruption PhenotypeSeedlings of the lacs6 and lacs7 double mutant were arrested in postgerminative growth due to inability to mobilize fatty acids into beta-oxidation, a necessary process to pursue the development. {ECO:0000269|PubMed:14742880}.
FunctionActivation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate, linoleate and eicosenoate. Displays redundant function with LACS7 into the seed development process (By similarity). {ECO:0000250}.
InductionUp-regulated by ozone and salt. {ECO:0000269|PubMed:16256065}.
InteractionQ9FMA3:PEX5; NbExp=4; IntAct=EBI-993851, EBI-993861;
PathwayLipid metabolism; fatty acid metabolism.
Sequence CautionSequence=BAC43213.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationPeroxisome {ECO:0000269|PubMed:12366803}.
SubunitInteracts with PEX5. {ECO:0000269|PubMed:16256065}.
Tissue SpecificityPreferentially expressed in seeds. {ECO:0000269|PubMed:16256065}.