LMPD Database

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LMP012354

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase bubblegum family member 1
Protein Entry
UniProt IDQ96GR2
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
FunctionMediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids
Sequence CautionSequence=BAA31606.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily
Subcellular LocationCytoplasm Cytoplasmic vesicle {ECO:0000250}. Microsome Endoplasmic reticulum
Tissue SpecificityExpressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary. {ECO:0000269|PubMed:10954726, ECO:0000269|PubMed:12975357}.