LMPD Database

LMP012414

UniProt Annotations

Entry Information
Gene Namelipoprotein lipase
Protein EntryLIPL_RAT
UniProt IDQ06000
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate.
FunctionThe primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity)
InductionInduced by insulin. Inhibited by isoproterenol
PtmTyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity
SimilarityBelongs to the AB hydrolase superfamily. Lipase family
SimilarityContains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular LocationCell membrane ; Lipid-anchor, GPI-anchor {ECO:0000250}. Secreted . Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl- glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity)
SubunitHomodimer (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids. Interacts with GPIHBP1 (By similarity)