LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012559

UniProt Annotations

Entry Information
Gene Namecarnitine palmitoyltransferase 1a, liver
Protein EntryCPT1A_RAT
UniProt IDP32198
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine. {ECO:0000269|PubMed:16908527, ECO:0000269|PubMed:21990363}.
DomainA conformation change in the N-terminal region spanning the first 42 residues plays an important role in the regulation of enzyme activity by malonyl-CoA
Enzyme RegulationInhibited by malonyl-CoA
FunctionCatalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism
PathwayLipid metabolism; fatty acid beta-oxidation.
SimilarityBelongs to the carnitine/choline acetyltransferase family
Subcellular LocationMitochondrion outer membrane {ECO:0000269|PubMed:16908527, ECO:0000269|PubMed:19136561, ECO:0000269|PubMed:21622568}; Multi-pass membrane protein {ECO:0000269|PubMed:16908527, ECO:0000269|PubMed:19136561, ECO:0000269|PubMed:21622568}.
SubunitHomohexamer and homotrimer. Identified in a complex that contains at least CPT1A, ACSL1 and VDAC1. Also identified in complexes with ACSL1 and VDAC2 and VDAC3
Tissue SpecificityLiver and kidney.