LMPD Database

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LMP012682

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 10
Protein EntryHCD2_RAT
UniProt IDO70351
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methylacetoacetyl-CoA + NADH.
Catalytic Activity(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
Catalytic ActivityTestosterone + NAD(P)(+) = androst-4-ene-3,17- dione + NAD(P)H.
FunctionFunctions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (By similarity)
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular LocationMitochondrion .
SubunitHomotetramer. Interacts with MRPP1/TRMT10C and MRPP3/KIAA0391 (By similarity)