LMPD Database

LMP012729

UniProt Annotations

Entry Information
Gene Namesolute carrier family 27 (fatty acid transporter), member 2
Protein EntryS27A2_RAT
UniProt IDP97524
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Catalytic ActivityATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.
FunctionAcyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity)
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein . Peroxisome membrane ; Multi-pass membrane protein . Note=Peripheral membrane associated with the lumenal side of peroxisomes.