LMPD Database

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LMP012843

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase long-chain family member 5
Protein EntryACSL5_RAT
UniProt IDO88813
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=666 uM for ATP ; KM=2.4 uM for CoA ; KM=8.6 uM for palmitate ; Vmax=130 nmol/min/mg enzyme with palmitate as substrate ;
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
FunctionAcyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL at the villus tip of the crypt-villus axis of the small intestine (By similarity). May have a role in the survival of glioma cells (By similarity). May activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. It was suggested that it may also stimulate fatty acid oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids. {ECO:0000250, ECO:0000269|PubMed:16263710, ECO:0000269|PubMed:17761945, ECO:0000269|PubMed:9722683}.
InductionExpression decreases in response to fast and increases after high sucrose diet
Miscellaneous5 rat isozymes encoded by different genes have been described. ACSL6 corresponds to isozyme 2 (ACS2)
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family
Subcellular LocationMitochondrion . Endoplasmic reticulum . Mitochondrion outer membrane ; Single-pass type III membrane protein . Endoplasmic reticulum membrane ; Single-pass type III membrane protein .
Tissue SpecificityExpressed most abundantly in the small intestine, and to a much lesser extent in the lung, liver, adrenal gland, adipose tissue and kidney